1921
Volume 49, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

The effects of artemether on the morphology of were studied in an owl monkey () when parasitemia reached 33% and the animal became severely ill. The earliest and the most distinctive ultrastructural changes following the administration of artemether were marked swelling of the mitochondria in the parasites, followed by the appearance of electron-dense chromatin materials in the nucleic and clumping of ribosomes. The initial change was observed within 2 hr of administration of the drug. These findings correlate well with the rapid and effective action of artemether, which has been demonstrated in human clinical trials.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1993.49.812
1993-12-01
2017-11-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1993.49.812
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error