Volume 49, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The ability of a selected strain of the malaria vector to encapsulate the early oocysts of the malaria parasite B has previously been shown to be genetically linked to specific esterase phenotypes. This association between susceptibility and esterase phenotype is found in the G3 strain from which the -refractory and -susceptible mosquio strains were derived. Genetic crosses had suggested that the esterase phenotypes reflect the assortment of two alleles at one esterase genetic locus, with the two esterase homozygotes showing -susceptible and -refractory phenotypes and the esterase heterozygote being intermediate in susceptibility. By using a variety of specific esterase inhibitors in conjunction with esterase staining of gel-electrophoresed mosquito homogenates, we found that the bands previously thought to reflect one genetic locus are actually the product of two different esterase loci, , a cholinesterase, and , a carboxyesterase. In addition, examination of chromosomal inversions and the esterase phenotypes in the G3 strain revealed that different forms of a polymorphic inversion on the left arm of chromosome two (the 2L inversion) are inseparably associated with different alleles at these two esterase loci. We conclude that the genetic association among the esterase-linked -susceptibility locus and the two esterase loci is maintained by the suppression of recombination in 2L inversion heterozygotes in the G3 strain and its selected derivatives.


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