Volume 49, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A group of 358 owl and squirrel monkeys imported from Colombia, Peru, and Bolivia for the U.S. Agency for International Development Malaria Vaccine Development Program was examined for trypanosomes and microfilariae. , isolated by hemoculture from , and , accounted for 76.6% of all trypanosome infections. was isolated from 25 of 194 , including two mixed infections with . Identifications of trypanosomes were confirmed by blinded tests with a panel of five rRNA probes on a subsample of cultures identified morphologically. Although no trypanosomes were isolated from or , positive serologic responses to were observed by indirect immunofluorescence assay in all species of monkeys examined and ranged from 42.1% among to 92.3% among . Among -infected monkeys, 43.7% were seronegative for . No microfilariae were found in or and were observed in in , and and in . Such naturally occurring infections in imported animal models are potential sources of accidental transmission to animal handlers and uninfected laboratory animals and can introduce confounding variables into otherwise well-planned and well-executed studies.


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