1921
Volume 49, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Several antibiotics that inhibit protein synthesis on 70S ribosomes, including the macrolide erythromycin, and the azalides azithromycin (ZITHROMAX™) and CP-63,956, demonstrated antimalarial activity against two strains of . In a four-day in vivo test, the azalides were 25-fold more potent than erythromycin against the chloroquine-sensitive N strain, and displayed additive effects with chloroquine. This effect was not observed with the erythromycin-chloroquine combination. Against the chloroquine-resistant MSU/RC strain, the azalides were 60-fold more potent than erythromycin. Additive effects were observed with azalide-chloroquine combinations against this strain, but these results were not significantly different from the erythromycin-chloroquine combination.

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/content/journals/10.4269/ajtmh.1993.49.101
1993-07-01
2017-09-19
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