Volume 48, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The antimalarial activity of β-artemether and β-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive parasites, in mice infected with , and in monkeys infected with chloroquine-resistant . In vitro, the mean 50% inhibitory concentration (IC) for β-artemether was 1.74 nM (range 1.34–1.81 nM), and this value for β-arteether was 1.61 nM (range 1.57–1.92 nM). They were approximately 2.5-fold more potent than artemisinin, which had a mean IC of 4.11 nM (range 3.36–4.60 nM). In the mouse model, the 50% curative doses (CD) of β-artemether and β-arteether had a mean value of 55 mg/kg (32–78 mg/kg). The 50% effective curative doses (ED) in the monkey were 7.1 mg/kg (95% confidence interval [CI] = 3.7–13.5) for β-artemether and 11.8 mg/kg (95% CI = 6.5–21.3) for β-arteether. Overall, the activities of the two drugs were comparable.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...


Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error