1921
Volume 48, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The antimalarial activity of β-artemether and β-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive parasites, in mice infected with , and in monkeys infected with chloroquine-resistant . In vitro, the mean 50% inhibitory concentration (IC) for β-artemether was 1.74 nM (range 1.34–1.81 nM), and this value for β-arteether was 1.61 nM (range 1.57–1.92 nM). They were approximately 2.5-fold more potent than artemisinin, which had a mean IC of 4.11 nM (range 3.36–4.60 nM). In the mouse model, the 50% curative doses (CD) of β-artemether and β-arteether had a mean value of 55 mg/kg (32–78 mg/kg). The 50% effective curative doses (ED) in the monkey were 7.1 mg/kg (95% confidence interval [CI] = 3.7–13.5) for β-artemether and 11.8 mg/kg (95% CI = 6.5–21.3) for β-arteether. Overall, the activities of the two drugs were comparable.

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/content/journals/10.4269/ajtmh.1993.48.377
1993-03-01
2017-09-24
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