Volume 47, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The pathologic changes in placentae of pregnant rats infected with at different stages of gestation were studied using light and electron microscopy and immunohistochemistry. The major changes observed were thickening and duplication of the trophoblastic basement membrane, and accumulation of parasitized erythrocytes and occasional mononuclear cells in the maternal blood space. Immunohistochemical examination of nine placentae revealed that six stained positively for IgG, two for IgM, and four for antigen. No C3 deposition was detected. The findings in this study indicate that the variable parasitologic-clinical course from benign to fatal of infection in pregnant rats makes it a potentially valuable model of human gestational malaria infection.


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