Volume 47, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The evolution of Lyme borreliosis was examined in genetically resistant C.B.-17 and susceptible C3H/He(C3H) mice homozygous for the severe combined immune deficiency () gene, or their immunocompetent counterparts. The C.B-17, C.B-17-, C3H, and C3H- mice were inoculated intradermally with 10 and examined on days 14, 21, 30, 45, and 60 after inoculation. Spirochetemia was detected through 30 days, but was cleared in all groups by 45 days. Kidney and brain were inconsistently culture positive, but spleen and ear punch samples were positive in most mice. Immunocompetent C.B-17 and C3H mice seroconverted with equivalent IgG titers to , while C.B-17- and C3H- mice did not seroconvert. Arthritis occurred in nearly all joints examined in all genotypes on day 14, was of equal severity among C.B-17, C.B-17-, and C3H mice, but was more severe in C3H- mice. By days 30 and 45, arthritis began to resolve in immunocompetent mice, with C3H mice having more severe disease than C.B-17 mice. Arthritis persisted in C.B-17- and C3H- mice. Carditis occurred to an equal degree in all groups on day 14, remained active in mice, but regressed in immunocompetent mice at later intervals. Many spirochetes were visualized with silver stain in inflamed synovial tissues of mice, and were present in other tissues in smaller numbers. These studies show that specific immunity is not involved in arthritogenesis or genetically determined susceptibility to arthritis, but is involved in arthritis and carditis regression.


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