Volume 47, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Abdominal ultrasonographic examination was performed in 61 hospitalized patients with chronic liver diseases and 253 school children from a village endemic for and were compared with 142 urban children without exposure to . The prevalence of ultrasound-detectable hepatomegaly and splenomegaly and the degree of periportal fibrosis was compared between those with and without infection. Among 13 patients with biopsy-proven schistosomal hepatic fibrosis, three with coarse changes secondary to infection showed grade III periportal fibrosis, while 10 patients with fine schistosomal hepatic fibrosis due to had borderline (two) or grade I (eight) changes. Ultrasound evidence of periportal fibrosis was not detected in patients with hepatic cirrhosis, chronic active hepatitis, or fatty infiltration. However, three of 14 patients with chronic persistent hepatitis had grade I periportal fibrosis and two had borderline changes. The frequency of ultrasound-detected hepatomegaly and splenomegaly was greater among rural -infected children (35.2% and 22.4%, respectively) than among noninfected rural (21.1% and 13.3%) and urban (16.9% and 4.9%) children. Also, the frequency of grade I periportal fibrosis was significantly greater ( (0.01) in -infected children (22.4%) than in noninfected rural (11.7%) and urban (0.7%) children. No patients with infections, either in the hospital or the village, had grade II or III periportal fibrosis. We conclude that infection with frequently causes mild degrees of periportal fibrosis from schistosomal hepatic fibrosis in the Assiut area, as well as hepatomegaly and splenomegaly, as evidenced by both ultrasound and by histopathologic examination, and that these milder ultrasonographic changes of periportal fibrosis can also have other etiologies, e.g., chronic hepatitis.


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