Volume 46, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



To elucidate the local release of immunomodulatory prostaglandins by intravascular filarial parasites, the formation of prostaglandin E (PGE) was examined in individual microfilariae of and . Following incubation of living microfilariae immobilized in an agar matrix, prostaglandins released by the parasites were fixed by carbodiimide and localized by indirect immunofluorescence. Prostaglandin E was specifically detected around the entire surface of microfilariae with anti-PGE antiserum, but not with control nonimmune or PGE affinity-immunoadsorbed antiserum. These results provide direct evidence that individual microfilariae of as well as release prostaglandins into their microenvironment. The release of PGE by these intravascular parasites may modulate host leukocyte responses, and thereby contribute to the immune defects observed in infected humans with peripheral microfilaremia.


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