Volume 46, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Patients infected with schistosomes may develop a clinical picture of chronic salmonellosis. We have investigated the altered function of macrophages capable of playing a role in the development of chronic salmonellosis associated with in an experimental model. The capacity of mouse peritoneal macrophages to ingest and kill was assessed in mice infected with with or without concurrent infection. Schistosomiasis was associated with a significant decrease in the phagocytic index of macrophages, due to the reduced number of cells engaged in phagocytosis. However, the number of bacteria ingested by these cells was comparable to that of the control group. The bactericidal capacity of macrophages from -infected mice was also significantly lower than that of cells from normal mice. Macrophages from animals infected only with showed an increased phagocytic capacity. It was concluded that infection alters phagocytosis and intracellular destruction of salmonellae. This demonstration of a novel mechanism of survival of salmonellae represents a step forward in understanding the pathogenesis and management of chronic septicemic salmonellosis.


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