Volume 44, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The frequency and numbers of sporozoites transmitted in vitro and corresponding sporozoite loads were determined for experimentally infected and . Geometric mean (GM) sporozoite loads in three experiments ranged from 808 to 13, 905 for and from 6, 608 to 17, 702 for . A total of 44.1% of 68 infected and 49.2% of 63 infected transmitted sporozoites in vitro. The GM number of sporozoites transmitted was 4.5 for and 5.4 for . Overall, 86.9% of the mosquitoes transmitted from one to 25 sporozoites, and only 6.6% transmitted over 100 sporozoites (maximum = 369). Sporozoite loads were not a useful predictor of potential sporozoite transmission. Despite higher sporozoite loads, the numbers of sporozoites transmitted in vitro by the experimentally infected mosquitoes were similar to estimates obtained, using the same techniques, for naturally infected in western Kenya. The low but highly variable numbers of sporozoites transmitted in vitro by mosquitoes used in malaria vaccine challenge studies appears to be a reasonable simulation of natural sporozoite transmission.


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