Volume 44, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The role of the spleen in resistance to infections with nonlethal is dependent upon the genotype of the host. Thus, DBA/2 (D2) mice infected with were not adversely affected by removal of the spleen, while splenectomized C57BL/6 (B6) or Balb/c mice failed to resolve their infections and eventually died. The levels of parasitemia were lower in splenectomized mice compared to intact controls; however, splenectomized mice became as anemic as did spleen-intact controls. Splenectomy resulted in the appearance of large aggregates of mononuclear cells in the livers of infected mice and also altered the liver/body weight ratios. These results indicate that D2 mice have a spleen-independent mechanism of clearing parasites which is lacking in B6 and Balb/c mice.


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