1921
Volume 44, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Animal models are needed for the study of cytoadherence in falciparum malaria. Red blood cell (RBC) rosette formation is one type of cytoadherence and appears to be associated with knob formation, endothelial cell adhesion and sequestration of -infected RBCs. Since -infected RBCs develop knobs and sequester, we hypothesized that they also form rosettes. RBCs from -infected rhesus monkeys () were collected, allowed to mature overnight in vitro and found to form rosettes as hypothesized. This observation adds to the known falciparum-like characteristics of , and suggests that the model may be appropriate for pathophysiologic studies of cytoadherence.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1991.44.399
1991-04-01
2017-11-23
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1991.44.399
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error