1921
Volume 44, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

We studied seroreactivity against antigens in 62 individuals living in a small community near Mantena, Minas Gerais, Brazil, an area outside the endemic malaria zone of Brazil. Eight months earlier, there had been transmission of for a period of 50 days, which was then totally controlled by chemotherapy and insecticides. An anti-sporozoite response, measured by ELISA using a recombinant protein expressed in yeast, was detected in 45% (14 of 31) of individuals eight months after infection and persisted for 20 months in 12%. Eighteen individuals were treated prophylactically for malaria because they lived in houses in which an overt infection had occurred. Seven of these individuals were ELISA positive; of these, 5 had antibodies against the blood stage parasites. Among 13 other individuals in the endemic area who did not have positive smears, had not been ill, and had not received prophylaxis, five were anti-circumsporozoite positive up to a 40-fold serum dilution. They did not develop asexual blood stage antibodies and remained parasite-free for the following 20 months.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1991.44.28
1991-01-01
2017-11-25
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1991.44.28
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error