Volume 43, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The extrinsic development of was observed in 2 manbiting sand flies, , a known vector, and , an assumed non-vector. Flies fed on a leishmanial lesion on the nose of a hamster were examined for infection at 0, 6, 12, 18, 24, 36, 48, and 60 hr and at ∼ 24 hr intervals from day 3 to day 14 post-feeding. Infection rates, determined by light microscopy, were 47% (n = 258) in and 5% (n = 162) in . Transformation from amastigotes to “procyclic” promastigotes occurred in both species at 6–18 hr post-feeding. In . the parasites multiplied rapidly and developed through as many as 10 forms, including at least 3 dividing-promastigote forms. Metacyclic promastigotes, the “infective” form, appeared at 6 days post-feeding, first in the region of the stomodeal valve, then in the pharynx, cibarium, and proboscis. In a single attempt 14 days post-feeding, a transmitted to a mouse by bite. In contrast, the parasites multiplied slowly in , and did not develop beyond “procyclic” promastigotes. The parasites did not migrate anteriorly nor survive beyond 90 hr post-feeding, indicating that is not a vector of . Classical strategies for vector incrimination may be confounded by the isolation of non-infective early developmental forms of from wild-caught non-vectors.


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