Volume 43, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Using inbred BALB/c and C57BL/6 mice as animal models for American cutaneous leishmaniasis, we evaluated the inhibitory effect of sinefungin on foot-pad infection produced by 5 different isolates. When treatment was initiated a few days, or even 2 weeks, after infection, an obvious leishmanicidal effect was detected on mice infected with or isolates, which lasted at least 50 weeks for all isolates studied. The optimal dose schedule was 4 mg/kg body weight/day, injected ip for 10 consecutive days; lower doses produced only a short leishmanistatic effect. The optimal dose found was 50-fold lower than the LD. In vitro studies using -infected murine peritoneal macrophages showed sinefungin as a powerful inhibitory drug, mean ED for the several isolates studied being 50 ng/ml. No correlation was found between in vitro sensitivity of culture promastigotes and in vivo sensitivity to sinefungin of an American isolate.


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