Volume 42, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



One week old LEW/N rats were inoculated with 15 different isolates of from 3 major North American (Northeast, Midwest, and Pacific) and 1 European endemic areas. At 30 days after inoculation, several tissues were cultured for and examined for histopathological changes. Sera were tested for IgM and IgG antibody to by an enzyme-linked immunosorbent assay. One or more isolates from each geographic region was recovered by culture and caused arthritis in the rats. No differences in pattern or severity of disease were apparent among pathogenic isolates. Several recovered isolates failed to infect rats, or did not cause disease. Rats that were actively infected seroconverted but uninfected rats did not. Infectivity and pathogenicity of isolates could not be correlated with molecular weights or expression of outer surface proteins based on agar gel electrophoresis.


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