Volume 42, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A circulating schistosome 70 kDa antigen (SJ 70) has been detected in the sera of mice infected with . For the detection of this antigen, a double antibody sandwich enzyme-linked immunosorbent assay (ELISA) was employed. SJ 70 is first detected in the serum of -infected mice 4 weeks after infection. Antigen levels rise rapidly, plateau by 7 weeks after infection, and remain relatively unchanged for at least another 9 weeks. In mice infected with for 7 weeks and then treated with praziquantel (100 mg/kg body weight), there is a significant decrease in serum antigen levels within 2 weeks after treatment, and an almost complete disappearance of antigen from the serum 3–4 weeks after treatment.


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