1921
Volume 42, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

We investigated the immunoregulatory function and properties of monocytes in 54 infected Egyptians (40–3,840 eggs excreted per gram of stool) 13–35 years of age. Adherent cell-mediated suppression was found in 11 of 36 patients. Cytochemical studies and reactivity with monoclonal antibodies directed at differentiation markers failed to show alterations in the distribution or maturation of monocytes. Peripheral blood mononuclear cells (PBMC) from these individuals produced lower levels of interleukin-1 (IL-1) in response to bacterial lipopolysaccharide and stimulation as compared to the other infected individuals. Overall, IL-1 production by PBMC stimulated with LPS or was higher in infected individuals compared to uninfected controls and correlated with intensity of infection (r = 0.41, = 0.002 for LPS; r = 0.45, = 0.006 for ). IL-1 expression by monocytes from individuals with heavy infection exceeded that of subjects with light infection. The intensity-related increase in IL-1 expression did not correlate with the maturational state or the immunoregulatory properties of the monocytes.

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/content/journals/10.4269/ajtmh.1990.42.234
1990-03-01
2017-09-26
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