1921
Volume 41, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Methemoglobin toxicities of primaquine and compound N-(3-acetyl-4-5-dihydro-2-furanyl)-N-(6-methoxy-8-quinolinyl) 1, 4-pentanediamine, CDRI Code 80/53, have been compared in beagles. Primaquine administration at 3 mg/kg for 7 days produced significantly high ( < 0.001) methemoglobinemia and the levels increased 10.55-fold. Compound 80/53 at 3.75 mg/kg × 7 days produced a marginal increase in methemoglobinemia (3.24-fold; < 0.02). The methemoglobin formed by primaquine administration was 3.65-fold ( < 0.001) higher than that formed after administration of compound 80/53. There was no significant change in other hematological parameters and liver function tests.

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/content/journals/10.4269/ajtmh.1989.41.638
1989-12-01
2017-11-22
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