1921
Volume 41, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

An analogue of primaquine, N-(3-acetyl-4-5-dihydro-2-furanyl)-N-(6-methoxy-8-quinolinyl) 1, 4-pentanediamine, CDRI Code 80/53), has been evaluated for anti-relapse activity against sporozoite induced infection in rhesus monkeys. The compound has shown 100% curative anti-relapse activity at 1.25 mg/kg × 7 day dose schedule, thereby giving a primaquine index of 0.8. The compound is currently under Phase-I clinical trials.

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/content/journals/10.4269/ajtmh.1989.41.635
1989-12-01
2017-11-25
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