Volume 41, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Monoclonal antibodies (Mabs) were developed against antigens from a pure culture of grown in modified SP-4 medium. All the Mabs obtained were shown to react only with , and not with other species of human mycoplasma. The Mabs identified immunohistologically in thymus, liver, spleen, lymph node, or brain from 22 patients with AIDS, as well as in 2 placentas delivered by patients with AIDS. Using an S-labeled DNA probe specific for and in situ hybridization technique, we also identified -specific genetic material in these tissues. Furthermore, ultrastructural studies of the specific areas of tissues which were highly positive for antigens revealed characteristic structures of mycoplasma organisms. These mycoplasma-like particles could be identified intracellularly and extracellularly. Histopathology of the tissues infected by varied from no pathological changes to fulminant necrosis with or without an associated inflammatory reaction. , a novel pathogenic mycoplasma, was cytopathic and cytocidal.


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