1921
Volume 41, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Ultrastructural observations were made of changes in the tegument and reproductive organs of and from ICR mice after treatment with praziquantel (PZQ), levo-PZQ, and dextro-PZQ at a single oral dose of 500 mg/kg body weight. No marked difference in types and extent of lesions of the tegument of was found between the compounds regardless of the time of worm recovery after treatment. This was equally true of . Degeneration of the testis, ovary, and vitelline gland of was more prominent in worms administered PZQ and levo-PZQ than in those receiving dextro-PZQ. In , extensive regression of the reproductive organs was observed in male and female worms treated with PZQ and dextro-PZQ, while no serious damage was seen in worms treated with levo-PZQ.

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/content/journals/10.4269/ajtmh.1989.41.204
1989-08-01
2017-11-18
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