1921
Volume 41, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Praziquantel (PZQ) is a racemic compound composed of equal proportions of its optical isomers, levo- and dextro-PZQ. The efficacy of these compounds was compared with that of PZQ in mice infected with or . Mice were given 50, 2 × 50 (on consecutive days), 500, or 2 × 250 mg/kg of each compound orally 5 weeks after infection. Significant reduction of worm recovery was observed in infection 30 days after treatment with 2 × 50, 500, or 2 × 250 mg/kg of levo-PZQ, whereas no therapeutic effect was demonstrated with dextro-PZQ. Percent reduction in worm burden in mice treated with levo-PZQ was significantly higher than in those with PZQ at a dosage of 2 × 50 mg/kg (67.9% vs. 34.5%). Neither eggs in feces nor miracidial hatching of eggs from the livers and intestines were observed in mice treated with levo-PZQ. In infection, levo-PZQ showed no significant schistosomicidal effect compared with PZQ and dextro-PZQ, although there was reduction in egg counts.

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/content/journals/10.4269/ajtmh.1989.41.198
1989-08-01
2017-09-25
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