1921
Volume 41, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

The drug susceptibility of 70 isolates of to standard and experimental antimalarials was evaluated using a radioisotope microdilution method. All isolates were from forest fringe dwelling Orang Asli, the aborigines of Peninsular Malaysia. The geometric mean IC values were: chloroquine, 10 ng/ml; amodiaquine, 4.7 ng/ml; mefloquine, 2.8 ng/ml; quinine, 40.5 ng/ml; halofantrine, 1.5 ng/ml; enpiroline, 3 ng/ml; and pyrimethamine, 21 ng/ml. Four isolates exhibited decreased susceptibility to chloroquine (IC > 60 ng/ml), and one exhibited decreased susceptibility to quinine (IC = 161 ng/ml). Three isolates showed decreased susceptibility to mefloquine (IC = 10–11 ng/ml). The lack of drug pressure may account for the high prevalence of isolates susceptible to chloroquine.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1989.41.1.TM0410010003
1989-07-01
2018-09-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1989.41.1.TM0410010003
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error