Volume 40, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The role of L3T4 and Lyt2 lymphocytes in the formation and modulation of granulomas around eggs was examined in athymic mice. Nude C57BL/6 mice infected with miracidia were compared to nude mice given normal spleen cells depleted of L3T4 or Lyt2 cells prior to infection and to intact mice. Nude mice formed small granulomas that were poor in eosinophils and connective tissue. Nude mice reconstituted with cells enriched for L3T4 or Lyt2 cells formed granulomas similar in size to those in intact mice, but granulomas in mice given Lyt2 cells contained few eosinophils and had significantly less collagen than did granulomas in mice given L3T4 cells. The same was true at 10 weeks. Mice reconstituted with null cells were examined at 7 weeks and formed granulomas similar to those in mice given Lyt2 cells. By 10 weeks after infection, granulomas had decreased to the same minute size in all groups of mice. Fibrosis increased at weeks 7–10 in all groups of mice.


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