Volume 40, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Genetic analysis of a system of refractoriness in suggests that the joint action of 2 unlinked genetic loci substantially controls expression of the susceptible and refractory phenotypes. One genetic component, here named Pif-B (for infectivity factor), is closely linked or identical to a polymorphic autosomal esterase locus which can be visualized by gel electrophoresis. This locus exerts the major controlling effect on susceptibility to B. The other genetic component is independent of esterase and exerts major control over refractoriness to the Ceylon strain parasite. Genetic assortment of the esterase-independent component suggests that it is controlled by 1 principal locus, here named Pif-C. The 2 genetic components of refractoriness appear to contribute to the same phenotype through physiologically independent means.


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