Volume 40, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Cross-sectional and longitudinal village-based studies of the transmission dynamics of an S-antigen serotype of the asexual erythrocyte stages of have been carried out in Madang, Papua New Guinea (PNG). Sera collected from village residents were screened for circulating S-antigen of the FC27 serotype by enzymelinked immunosorbent assay (ELISA). The prevalence of the FC27 S-antigen was found to vary between villages at a given point in time, as well as within a village over time. Residents of villages 2–5 km apart were infected with of different S-antigen serotypes. This study documents the periodic nature of transmission of a sub-population of defined by the FC27 S-antigen. The variation in a small area in the prevalence of this serotype of in Madang illustrates the complexities of malaria transmission which must be considered in the design of malaria vaccine trials.


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