1921
Volume 40, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Using blood from volunteers with sporozoite induced malaria, a comparison was made of the sensitivity and specificity of Giemsa stained thick film examination, in vitro culture, and 4 different DNA probes for detecting parasitemia. Between 9 and 13 days after sporozoite inoculation, patent parasitemia (4–550 parasites/µl) was detected by thick film examination of 0.5 µl blood in 7 volunteers. Cultures of 1 ml blood obtained 7 days after sporozoite inoculation were positive in all volunteers who eventually developed patent parasitemia. The DNA hybridization probes detected parasites in only 5–28% of smear- or culture-positive samples.

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/content/journals/10.4269/ajtmh.1989.40.3
1989-01-01
2017-09-24
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1989.40.3
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  • Accepted : 23 Sep 1988

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