1921
Volume 40, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

From a panel of mouse monoclonal antibodies reactive with a repeating epitope of the schistosome circulating anodic antigen, an IgG monoclonal antibody was selected. This monoclonal antibody was applied in a sandwich enzyme-linked immunosorbent assay as capture antibody and as alkaline phosphatase labeled conjugate.

This assay allowed a sensitive quantitation of circulating anodic antigen in serum samples of infected individuals, detecting < 1 ng antigen/ml serum.

In infected individuals from Zaire, the level of antigen in serum correlated with fecal egg output. The lower detection level of the immunoassay corresponded to a level of about 10 eggs/gm feces.

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/content/journals/10.4269/ajtmh.1989.40.268
1989-03-01
2017-11-21
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