Volume 39, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Ivermectin was tested for possible prophylactic action against the third and fourth larval stages (L and L) of inoculated into chimpanzees. The infective larvae (L) were obtained from laboratory-raised black flies. Eighteen chimpanzees were inoculated, each with approximately 250 L. Six were treated with ivermectin (200 µg/kg) on the day of inoculation, 6 were treated with ivermectin on day 28, and 6 were not treated. Monthly skin snips were taken for the next 30 months to detect patent infection. One of the chimpanzees treated with ivermectin on the day of infection developed a patent infection as did 4 of the 6 treated at day 28 and 4 of the 6 control animals. The results suggest that ivermectin may have a partial in vivo effect against the L of but has no effect against later larval stages of the parasite.


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