1921
Volume 39, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

A serologic survey and experimental virus transmission studies were done to assess the role of domestic animals as amplifier hosts of La Crosse (LACV) and Jamestown Canyon (JCV) viruses. Serum from 319 cows, 88 dogs, 122 equines, 47 swine, 10 goats, and 4 cats were tested for neutralizing antibody to LACV, JCV, trivittatus (TVTV), and snowshoe hare (SSHV) viruses. Antibody prevalences of LACV, TVTV, and SSHV were less than 10% in all species. Antibody to JCV was detected in all species except cats. Prevalence ranged from 10% in goats and swine to 29% in dogs. No age-associated trends in JCV prevalence were noted. Two of 6 adult dogs, and 2 of 4 pigs inoculated with 6.3–6.5 log suckling mouse intracerebral 50% lethal doses (SMICLD) of LACV developed viremias ranging of <1.0–2.9 log SMICLD/ml 1–3 days after inoculation. Of 4 puppies inoculated with LACV, 3 developed fatal infections. Viremias were not detected in 4 cows, 4 ponies, 7 cats, or 6 sheep. Two cats fed LACV infected suckling mice shed virus from the oropharynx for 1 day each. All animals except 1 cow, 1 cat, and 1 sheep had ≥ 4-fold rise in antibody titers. Five additional dogs fed upon by LACV-infected mosquitoes did not develop viremias or antibody and uninfected engorging on the dogs 1–5 days after feeding by infected mosquitoes failed to become infected. Five ponies, 6 calves, 2 ewes, 6 dogs, and 5 piglets were inoculated with 3.6–7.3 log SMICLD of JCV. None developed detectable viremias, although ≥ 4-fold rises in antibody titers developed in 60% of the ponies, 17% of the calves, 50% of the dogs, and 1 of 2 ewes. None of the pigs developed corresponding rises in antibody titers. We conclude that juvenile and adult animals of the species tested are not efficient amplifier hosts of LACV or JCV, but may be useful sentinels of local virus transmission.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1988.39.409
1988-10-01
2017-09-24
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1988.39.409
Loading
  • Accepted : 09 May 1988

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error