1921
Volume 39, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

To gain better understanding of the natural history of associated disease, age- and intensity-related urinary tract morbidity were assessed in a cross-sectional study of Kilole (population 719) in Coast Province, Kenya. Overall prevalence of infection was 65% (39% light, 16% moderate, 9% heavy). Infection prevalence and mean intensity of infection were highest in the 5-14-year-old bracket for both sexes. Although significant intensity-associated increases in hematuria prevalence were noted for both children and adults in all infection categories, hematuria was more common in those < 15 years of age. Children had a significant increase in the prevalence of dysuria at higher levels of infection, whereas adults did not. Radiographic study of a 1:9 random sample, stratified for age, revealed a greater prevalence of urinary tract granulomas in those < 15 years. Subjects > 15 years of age had a greater frequency of hydronephrosis. Hydronephrosis, hydroureter, and bladder calcification were not associated with higher infection intensity.

Among individuals with bladder calcification, a potential marker of cumulative inflammation, 87% had hydronephrosis or hydroureter, compared to a 40% prevalence among individuals without bladder calcification. These findings suggest that certain structural forms of urinary tract disease, such as hydronephrosis, progress during the course of untreated schistosomiasis haematobia despite age-related reductions in egg burden, whereas other forms of morbidity, such as hematuria, remain sensitive to the level of urinary egg excretion at the time of diagnosis.

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/content/journals/10.4269/ajtmh.1988.39.361
1988-10-01
2017-11-21
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1988.39.361
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  • Accepted : 25 Feb 1988

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