1921
Volume 39, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The activity of desferrioxamine (Desferal) and desferrithiocin (a newly developed oral iron chelator) was evaluated against the liver stage of and in the rodent and the human hepatocyte in vitro culture system. The two iron chelators were found to inhibit the liver schizogony of both the rodent and the human species at concentrations achievable in vivo. proved to be more sensitive (ic 95% below 20 micromol/l than (ic 95% 50–100 micromol/l). As assessed by electron microscopy, drug administration was associated with focal clarification of the cytoplasm thought to be reversible.

As desferrioxamine and desferrithiocin are known to be equally active on the blood stage of rodent and human plasmodia, iron chelators are deserving of further investigation as potential alternative candidates to existing drugs for radical cure of malaria.

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/content/journals/10.4269/ajtmh.1988.39.236
1988-09-01
2017-09-26
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1988.39.236
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  • Accepted : 01 Mar 1988

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