Volume 38, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Leukocyte subsets present in the granulomatous response produced after the inoculation of a mixture of and BCG in lepromatous leprosy patients were characterized in situ using monoclonal antibodies and an immunoperoxidase technique. The granuloma produced after -BCG inoculation showed a distribution pattern similar to tuberculoid granulomas. T lymphocytes bearing the CD8 phenotype (T cytotoxic/suppressor) were sequestered to the periphery of the epithelioid tubercles and T helper-inducer CD4+ lymphocytes were distributed throughout the infiltrate. Langerhans cells CD1 + were increased in the epidermis, and in dermis they were localized mainly in the mantle surrounding the granuloma. Most of the dermal infiltrate produced after the inoculation or -BCG expresses the HLA-DR antigen. Similarly, most keratinocytes were also positive to this MHC antigen. The granulomatous response to BCG was similar to the inoculation of a mixture of -BCG, however acid-fast bacilla were still present. The inoculation of produced a macrophage granuloma with no clearing of the bacilla which resembles the lepromatous leprosy granuloma.


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