1921
Volume 38, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Arachidonic acid (20:4) conversion to prostanoids was examined in murine peritoneal macrophages infected in vitro with . Four strains of mice differing in resistance to in vivo infection were studied. Normal macrophages from all strains converted 20:4 to prostanoids and this was augmented by infection. Although cells from each strain synthesized elevated levels of prostaglandin-E (PGE), there were differences with respect to relative increases of this product, with infected macrophages from the C3H/HeJ strain showing the smallest increase above basal levels.

These results indicate that macrophages from mouse strains with distinct levels of in vivo resistance to all respond to infection with augmented prostanoid synthesis. Although some heterogeneity in strain-specific PGE responses to in vitro infection were observed (with respect to increases in PGE synthesis above basal levels), it is unlikely that differential resistance of these strains to in vivo infection is strictly related to these relative differences. It seems likely that other genetically controlled factors may have a major impact on disease expression.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1988.38.59
1988-01-01
2017-09-23
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1988.38.59
Loading
  • Accepted : 07 Jul 1987

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error