1921
Volume 38, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Lymphocyte proliferative responses to the candidate malaria sporozoite vaccine antigen R32 were evaluated in 29 patients with acute malaria, 20 convalescent patients, 11 nonimmune individuals, and 22 healthy residents of two endemic malarious areas in Thailand. The results indicate that 14 of 20 (70%) convalescent patients and 14 of 22 (64%) residents of endemic areas responded to the R32 antigen. However, only 8 of 29 (28%) patients with acute malaria responded. When 4 of the convalescent patients who remained in a malaria-free area were restudied 5–10 months after the acute infection, they were either not responsive or their responses had greatly diminished. These findings show that sensitization to R32 occurs following a natural infection, but the cellular immune response to sporozoite antigens may be short-lived and may be suppressed during acute malaria.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1988.38.37
1988-01-01
2017-09-26
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1988.38.37
Loading
  • Accepted : 16 Jul 1987

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error