Volume 38, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The rate of phosphorylation of 2-deoxyglucose (2DG) was determined by sequential pulsing of schistosomes (male and female ) with [H- and C]-2-deoxy-D-glucose. The relative phosphorylation rate of 2-[H]-2DG to 1-[C]-D-glucose (i.e., the phosphorylation coefficient) was also measured in male and female schistosomes. Even though 2DG is taken up more rapidly than glucose, it is phosphorylated at a much slower rate in . Mated schistosomes phosphorylate 2DG and glucose at a greater rate than do unmated worms. In contrast, the phosphorylation coefficient is greater in separated than mated schistosomes. In schistosomes exposed to oltipraz for short time periods (6 min, at a concentration of 10 µg/ml) glucose utilization rates were significantly reduced in (both mated and separated) female and by a similar magnitude (not significant) in males.


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