Volume 38, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Patent infections with the lymphatic filariae, and , are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftian filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as “responders” to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to antigen (stimulation ratio > 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean reactivity (15,822 vs. 4,538 cpm, < 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or -specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.


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