Volume 37, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Squirrel monkeys protected after vaccination with a particular protein fraction of elicit antibodies directed against two parasite proteins, M 90,000 and 72,000. We have used monoclonal antibodies and sera from protected monkeys to determine whether or not these polypeptides were polymorphic in 22 strains. In all the isolates studied, both polypeptides were conserved, as was the epitope defined by monoclonal antibody XIV/7 present on the M 90,000. Immunofluorescence of all strains showed the same pattern using 5 Mab produced against different fragments of the M 72,000 polypeptide from the FUP strain. All isolates examined were positive, indicating that this polypeptide was present in different strains and that the 5 epitopes were conserved. Peptide mapping of both the M 90,000 and 72,000 antigen purified from 3 different strains indicated that each antigen appeared to be conserved.


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