1921
Volume 37, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

α-difluoromethylornithine had no inhibitory effect on the growth of , while methylglyoxal bis(guanyl-hydrazone) and sinefungin completely blocked amebic growth at 2.5 mM and 5 µg/ml concentrations, respectively. Cyclohexylamine caused only partial inhibition of amebic growth at 50–200 µM concentrations. Methylglyoxal bis(guanyl-hydrazone) inhibited S-adenosylmethionine decarboxylase of indicating this enzyme to be the target for its antiamebic action. This enzyme was, however, not inhibited by sinefungin, suggesting an alternative target for growth inhibition by this compound.

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/content/journals/10.4269/ajtmh.1987.37.550
1987-11-01
2017-11-18
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1987.37.550
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  • Accepted : 15 May 1987

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