Volume 37, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Calves were immunized twice in 4 weeks with a cross-reactive, cross-protective defined immunity antigen (denoted Fh isolated from adult worm extracts by antibody affinity chromatography and challenged 7 weeks later with metacercariae. F1ukes were recovered at 16 weeks of infection at which time the immunized calves had 55% less than the controls. All of the immunized calves developed high antibody levels of Fh, detectable in the ELISA, by 4 weeks after a single immunization. By 9 weeks of infection with the immunized calves had lower sorbitol dehydrogenase levels than the unimmunized, -infected control calves, indicating less liver damage in the vaccinated group. These studies demonstrate that subcellular macromolecules cross-reactive and cross-protective against also have the potential to serve as vaccines in cattle exposed to this parasitic disease.


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  • Published online : 01 Sep 1987
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