1921
Volume 36, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The ultrastructural changes induced by the administration of a recently developed antimalarial drug, mefloquine, were studied in mice infected with and human erythrocytes infected with in vitro. Pronounced changes which occurred in both experiments comprised swelling of the parasites' food vacuoles with gradual loss of pigment granules, which did not form clumps as occurs with chloroquine. These findings suggest that the malarial parasites' food vacuole is the target of this drug.

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/content/journals/10.4269/ajtmh.1987.36.9
1987-01-01
2017-09-22
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1987.36.9
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  • Accepted : 03 Jul 1986

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