Volume 36, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The fungicidal activity of murine polymorphonuclear neutrophils from the peripheral blood or elicited intraperitoneally with thioglycollate or with antigen in -sensitized or nonsensitized mice was studied. Although peripheral blood, thioglycollate-elicited, and antigen-elicited neutrophils from normal mice or thiogly-collate-elicited neutrophils from -sensitized mice killed (57% to 84%), they failed to significantly reduce inoculum colony forming units of (0% to 13%). In contrast, antigen-elicited neutrophils from sensitized mice reduced colony forming units of by 40%, and exhibited significantly enhanced candidacidal activity compared to thioglycollate-elicited neutrophils from normal or sensitized mice but not peripheral blood neutrophils from normal mice. Fresh serum, but not specific antibody, was required for optimal killing of , presumably representing an essential role for complement. Killing of by antigen-elicited neutrophils from sensitized mice correlated with their ability to produce an enhanced oxidative burst, as measured by luminol-assisted chemiluminescence, when interacting with killed cells. These results indicate that in -sensitized hosts an inflammatory reaction to results in activation of neutrophils for significant killing of the pathogen.


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