Volume 36, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Nine cases of asymptomatic alveolar hydatid disease (AHD) of the liver were diagnosed in 1985 among Eskimos from the endemic region of western Alaska. The patients were identified by screening with the enzyme-linked immunosorbent assay, using purified antigen (Em ELISA). Five patients, and one diagnosed earlier (1979), were found to have lesions in which the larval had died spontaneously at an early stage of infection. Viability was assessed histologically; by the avidinbiotin immunohistochemical method; and in vivo through intraperitoneal inoculation of membranes of the larval cestode into red-backed voles, . The results were in agreement with the clinical impression, based on findings by computerized tomography and ultrasound scanning, and on the macroscopic appearance of the lesions, that the cestode was dead. Spontaneous death of in humans has not been previously reported. The findings show that the Em ELISA may be positive in patients having lesions of AHD in which the etiologic agent is no longer viable.


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