1921
Volume 36, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Because dual infection with and hepatitis B may lead to severe liver disease, populations living in schistosomiasis-endemic areas might benefit if effectively immunized against hepatitis B. To determine whether a plasma-derived hepatitis B vaccine is immunogenic in patients with schistosomiasis, 32 individuals infected with were given three 20-µg doses of Heptavax-B vaccine and treated with praziquantel. Antibody to hepatitis B surface antigen developed in 90.6% of the study subjects after three doses of vaccine. Five patients (15.6%) had a weak response to the vaccine, and three patients (9.4%) failed to develop antibody. A weak or failed response to the vaccine was significantly associated with the presence of hepatosplenomegaly. A plasma-derived vaccine is immunogenic for persons infected with ; however, vaccine response is diminished in hepatosplenic schistosomiasis.

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/content/journals/10.4269/ajtmh.1987.36.549
1987-05-01
2017-11-19
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1987.36.549
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  • Accepted : 31 Oct 1986

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