Volume 36, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Two ornithine decarboxylase inhibitors, DL-α-difluoromethylornithine (eflornithine; DFMO) and a-monofluoromethyldehydroornithine methyl ester (ΔMFMO·CH) were compared in their ability to cure two distinct central nervous system murine model infections. Both inhibitors cured the TREU 667 and LUMP 1001 isolates if used in combination with a single (20 mg/kg) injection of suramin, a trypanocide in current clinical use. The curative dose of ΔMFMO·CH in combination with suramin was 1.09 g/kg/day, administered in the drinking water for 14 days; used with suramin, the curative dose of DFMO was 5.3 g/kg/day for 14 days (5 times the ΔMFMO·CH dose required). In host animals, ΔMFMO·CH was not toxic and was accumulated by trypanosomes 6–8 times faster than DFMO. Since DFMO by itself has been highly effective against infections in humans (12–15 g/day for 6 weeks) the present data suggest that ΔMFMO·CH might be effective in a shorter regimen and at lower doses.


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