1921
Volume 36, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Two ornithine decarboxylase inhibitors, DL-α-difluoromethylornithine (eflornithine; DFMO) and a-monofluoromethyldehydroornithine methyl ester (ΔMFMO·CH) were compared in their ability to cure two distinct central nervous system murine model infections. Both inhibitors cured the TREU 667 and LUMP 1001 isolates if used in combination with a single (20 mg/kg) injection of suramin, a trypanocide in current clinical use. The curative dose of ΔMFMO·CH in combination with suramin was 1.09 g/kg/day, administered in the drinking water for 14 days; used with suramin, the curative dose of DFMO was 5.3 g/kg/day for 14 days (5 times the ΔMFMO·CH dose required). In host animals, ΔMFMO·CH was not toxic and was accumulated by trypanosomes 6–8 times faster than DFMO. Since DFMO by itself has been highly effective against infections in humans (12–15 g/day for 6 weeks) the present data suggest that ΔMFMO·CH might be effective in a shorter regimen and at lower doses.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1987.36.46
1987-01-01
2017-11-17
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1987.36.46
Loading
  • Accepted : 10 Jul 1986

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error