Volume 36, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We determined if deer mice () could be infected by and develop sufficient spirochetemia to infect larval . Ten were infected orally with 0.05 ml phosphate buffered saline containing approximately 400 . On days 21 or 28 after infection (AI) larval were fed on the deer mice. Each of the developed antibodies (up to 7 log) to and was isolated from the blood of 1 deer mouse on day 51 AI. Nymphs resulting from these larvae were then allowed to feed on 10 uninfected . All 10 of these tick-infected developed antibodies (up to 7 log) to , and was isolated from the blood of 1 of the 10 15 days after tick feeding and from the pooled organs of another of the tick-infected . Six of the orally infected developed clinical signs including ruffled hair coat, inappetence, reluctance to move, and lameness in the rear legs. All tissues were grossly and histologically normal on necropsy. These findings show that are susceptible to oral infection and develop sufficient spirochetemias to infect larvae.


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