Volume 36, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Human erythrocytic culture-adapted parasites of the Geneve/SGE-1 strain of were successfully adapted to grow in an in vitro culture system containing squirrel monkey erythrocytes and serum. These monkey culture-adapted organisms were then used to produce a patent infection in a splenectomized squirrel monkey. Fresh infected blood from this animal was introduced into another splenectomized monkey and was subsequently serially passed through seven intact squirrel monkeys. High level parasitemias (> 10%) were obtained in the animals from the last two passes following inoculation of moderate numbers of parasites. It is anticipated that this squirrel monkey-adapted Geneve/SGE-1 strain of will continue to produce high level parasitemias in intact Bolivian , and consequently will be suitable for challenge of these monkeys.


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