1921
Volume 36, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The effect of temperature on the ability of to transmit dengue (DEN) 2 virus to rhesus monkeys was assessed as a possible explanation for the seasonal variation in the incidence of dengue hemorrhagic fever in Bangkok, Thailand. In two laboratory experiments, a Bangkok strain of was allowed to feed upon viremic monkeys infected with DEN-2 virus. Blood-engorged mosquitoes were separated into two groups and retained at constant temperatures. Virus infection and transmission rates were determined for at intervals ranging from 4 to 7 days during a 25-day incubation period. Results of the first experiment for mosquitoes infected with a low dose of DEN-2 virus and maintained at 20, 24, 26, and 30°C, indicated that the infection rate ranged from 25% to 75% depending on the incubation period. However, DEN-2 virus was transmitted to monkeys only by retained at 30°C for 25 days. In the second experiment, the infection rate for that ingested a higher viral dose, and incubated at 26, 30, 32, and 35°C ranged from 67% to 95%. DEN-2 virus was transmitted to monkeys only by mosquitoes maintained at ≥30°C. The extrinsic incubation period was 12 days for mosquitoes at 30°C, and was reduced to 7 days for mosquitoes incubated at 32°C and 35°C. These results imply that temperature-induced variations in the vector efficiency of may be a significant determinant in the annual cyclic pattern of dengue hemorrhagic fever epidemics in Bangkok.

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/content/journals/10.4269/ajtmh.1987.36.143
1987-01-01
2017-11-18
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1987.36.143
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  • Accepted : 26 Jun 1986

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